منابع مشابه
Cell surface receptors, virus entry and tropism of primate lentiviruses.
Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain entry into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds both CD4 and a seven-transmembrane coreceptor. These interactions trigger conformational changes in the envelope spike that induce fusion of viral and cellular membranes and entry of the viral core into the cell cy...
متن کاملReplication of lentiviruses.
Lentiviruses belong to a subfamily of the retroviruses usually associated with persistent infections in animals and humans. They have complex replication cycles involving numerous regulatory and accessory proteins, which sets them apart from the oncoretroviruses and spumaviruses, the two other main subfamilies of the retroviruses. Studies over the years have elucidated the various molecular mec...
متن کاملOral transmission of primate lentiviruses.
Oral transmission of human immunodeficiency virus type 1 (HIV-1) is well documented in children who become infected postnatally through breast milk. In contrast, epidemiologic surveys have yielded conflicting data regarding oral HIV-1 transmission among adults, even though case reports have described seroconversion and the development of AIDS in adults whose only risk was oral-genital contact. ...
متن کاملBiology and pathogenesis of lentiviruses.
Lentiviruses are a family of retroviruses linked by similarities in genetic composition, molecular mechanisms of replication and in biological interactions with their hosts. They are best known as agents of slow disease syndromes that begin insidiously after prolonged periods of subclinical infection and progress slowly leading to the degeneration of multiple organ systems, cachexia and death. ...
متن کاملAncient lentiviruses leave their mark.
O ne of the most remarkable insights from the human genome project was that more genetic material is devoted to vertically transmitted and defective remnants of once-infectious retroviruses, commonly referred to as endogenous retroviruses (ERVs), than to human protein-coding DNA (1). Current estimates place the ERV component of the human genome at 5–8%, comprising at least 31 distinct families,...
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ژورنال
عنوان ژورنال: MEMBRANE
سال: 2005
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.30.73